甘油磷酰胆碱 ( Choline glycerophosphate )

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                甘油磷酰胆碱 ( Choline glycerophosphate )

                分类:植物原料 2020年12月26日 阅读

                简介:


                L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a naturalcholine compound found in the brain and in milk. It is also a parasympathomimeticacetylcholine precursor which may have potential for the treatment of Alzheimer's disease and dementia. Alpha-GPC is also used as a nootropic dietary supplement to enhance memory and cognition.
                甘油磷酰胆碱 ( Choline glycerophosphate )
                甘油磷酸胆碱(GPC),是人体内正常存在的水溶性小分子物质,是重要的神经传递介质乙酰胆碱(Acetylcholine)的生物↑合成前体。GPC最重要的作用在于其产生的胆碱为水溶性维生素B族,对大脑和神经」系统具有重要作用,研究显示GPC对某些激素和神经传递介质如乙酰胆碱和人生长激素☆的产生具有重要作用,由此支持大脑和神经▼系统的功能。

                理化性质:

                甘油磷酰胆碱(GPC) 可与〗水混溶,能溶于甲醇、乙醇,不溶于氯仿、醚、油等,在紫外可见光下无特征吸收。GPC 含量测定方法有高效液相色谱法( 配备蒸发光散射检测器或折光示差检测器) 和消化定磷法。

                药理作用:

                甘磷酸胆碱是一个在人体中自然存在的磷脂代】谢的中间体,存在于细胞并遍及人体,结构上由胆碱、甘油、磷酸组成,它是胆碱的一种主要保存形式,被公认为胆碱的来源。因属于内源性物质故毒副作用极低。甘磷■酸胆碱吸收后在机体内酶的作用下分解成胆碱和甘油磷酸脂:其中胆碱参加乙酰胆碱的生物合成,乙酰胆碱是神经触发递质的一种;甘油磷酸脂是卵磷脂的前身,参与卵磷脂的合成。主要药理作用,包括保护胆碱的新陈代谢作用,保证乙酰胆碱和卵磷脂在神经膜合成,改善血液循环;对于脑部毛细神经受创的病人改善认知和行为反应。而在这一领域,尚没有更优的新型药物上市或研发。

                生物学功能:


                甘油磷酸胆碱不仅是肾髓质细胞的主要渗透物之一,而◥且能够平行的改变细胞内外渗透物质的浓度。这对于脑血管的健康,尤其是有益于因大脑衰退而引起的行为和情感障碍。甘油磷酸胆碱具有对于多种生化病变进行治疗和预防的潜在能力。研究人员发现它可以改变神经元膜中的磷酸盐类脂化合物结构,并且在引发神经组织衰退综合症的相关因素中发现它具有缓解身体紧张性的奇特功效。

                甘油磷酸胆碱的应用:


                甘油磷酸胆碱已经在意大利、波兰、希腊、智利、韩国、巴西、俄罗斯等国家上市。它不仅能够提供脑细胞和神经细胞所需要的高★水平胆碱,而且还能保护其细胞壁。阿尔兹海默症患者主要表现为记忆力与认知功〓能下降,并且伴有多种并发症,如行动不便、神经系统紊乱∏等功能性障碍。临床的药理学试验结果和临床试验都已证实甘油磷酸胆碱对大脑的认知能力和记忆功能大有帮助。

                Alpha GPC is a chemical released when a fatty acid found in soy and other plants breaks down. It is used as medicine.
                In Europe alpha-GPC is a prescription medication for the treatment of Alzheimer s disease. It is available in two forms; one is taken by mouth, and the other is given as a shot. In the United States alpha-GPC is only available as a dietary supplement, mostly in products promoted to improve memory.Other uses for alpha-GPC include treatment of various kinds of dementia, stroke, and “mini stroke” (transient ischemic attack, TIA).
                Alpha-GPC is also used for improving memory, thinking skills, and learning.

                功效 & Function


                1. Increases human Growth Hormone (hGH)
                Increases in endogenous human Growth Hormone (hGH) secretion by the anterior pituitary in conjunction with Growth Hormone Releasing Hormone (GHRH); that is, both Alpha-GPC and GHRH act concertedly to stimulate the release of hGH, naturally;

                2. More strength from work-outs and training programs
                Acts as a precursor of acetylcholine (ACh); thus, Alpha-GPC activates cholinergic transmission which permits the development of more strength from work-outs and training programs, plus reducing levels of somatostatin in the hypothalamic-pituitary axis;

                3. Improved lipotrophic functions in the liver
                Elevations in blood and tissue levels of the essential nutrient, choline, which supports improved lipotrophic functions (methyl group transferases) in the liver. Research has shown that fatty liver, a condition associated with obesity, diabetes and heavy alcohol consumption, often leads to cirrhosis of the liver or liver failure. Studies conducted by Alan L. Buchman, M.D., associate professor of medicine at The Feinberg School of Medicine at Northwestern University, have shown that fatty liver can be prevented and possibly even eliminated with increased levels of choline. Alpha-GPC also acts synergistically with the body's store (and/or supplementation) of S-adenosyl-L-methionine (SAM or SAMe) and folic acid, vitamin B12 and vitamin B6 to facilitate methyl group transfers in the brain and liver;

                4. Improved balanced and coordination
                Produces improved balanced and coordination when combined with 'skill set' practice and training as a result of normalized nerve transmission in the brain, and in cardiac, skeletal and smooth muscles.

                 

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